Zein/MCM-41 Nanocomposite Film Incorporated with Cinnamon Essential Oil Loaded by Modified Supercritical CO2 Impregnation for Long-Term Antibacterial Packaging.

Xiaojing Liu,Ziling Lian,Fahuan Ge,Anya Xiang,Jingfu Jia,Shulei Duan,Xue Zhou

doi:10.3390/pharmaceutics12020169

Xiaojing Liu, Ziling Lian + Show 5 more

Open Access

https://doi.org/10.3390/pharmaceutics12020169

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Abstract

Antimicrobial medicine and food packages based on bio-based film containing essential oils have attracted great attention worldwide. However, the controlled release of essential oils from these film nanocomposites is still a big challenge. In this study, a long-term antibacterial film nanocomposite composed of zein film and cinnamon essential oil (CEO) loaded MCM-41 silica nanoparticles was prepared. The CEO was loaded into MCM-41 particles via modified supercritical impregnation efficiently with a high drug load (>40 wt%). The morphologies of the prepared nanoparticles and film nanocomposite were characterized by a scanning electron microscope. The release behaviors of CEO under different temperatures, high humidity, continuous illumination and in phosphate buffer solution (PBS) solution were investigated. The results showed that the film nanocomposite had an outstanding release-control effect. The addition of MCM-41 nanoparticles also improved the mechanical properties of zein films. The antibacterial effect of CEO was significantly prolonged by the film nanocomposite; indicating the CEO film nanocomposite fabricated via modified supercritical CO2 impregnation was a potential long-term antibacterial medicine or food package material.

Highlights

With increasing concerns about the environment, ecology and safety in the last decade, biodegradable medicine and food packaging materials have gained more and more attention all over the world [1]
The morphology of the prepared silica MCM-41 and cinnamon essential oil (CEO)@MCM-41 particles were observed by SEM, and the images are shown in Figure 1A,B, separately
Both powders had spherical particles with uniform diameters around 50 nm, indicating that loading CEO into MCM-41 by supercritical impregnation brought no change to the particle morphology

Summary

Introduction

With increasing concerns about the environment, ecology and safety in the last decade, biodegradable medicine and food packaging materials have gained more and more attention all over the world [1]. These film materials normally originated from regenerative resources such as proteins, lipids, cellulose, polysaccharides, lactic acid, and so on [2,3,4]. For the purpose of extending the shelf-life or avoiding microbial contamination, active packaging materials generated via the incorporation of bio-based films and antimicrobial components such as essential oils, were developed [5,6].

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