Year-end Sale % OFF 
Abstract
Transcriptome analysis of a zebrafish mutant that does not respond to amphetamine identifies a network of coordinated gene regulation that may underlie the susceptibility to addiction.
Highlights
Addiction is a pathological dysregulation of the brain's reward systems, determined by several complex genetic pathways
We recently developed a robust assay for amphetamineinduced conditioned place preference (CPP) behavior in adult zebrafish, and demonstrated the role of acetylcholine signaling in the sensitivity to amphetamine-induced reward [17,21]
The mutant nad fails to respond to amphetamineinduced reward To recover mutants of the amphetamine response, we designed an ENU mutagenesis screen making use of the amphetamine-based CPP test for adult zebrafish [21]
Summary
Addiction is a pathological dysregulation of the brain's reward systems, determined by several complex genetic pathways. Addictive drugs include a large number of substances (such as stimulants, alcohol and opiates) acting through different cellular mechanisms, but which all trigger a sequence of widespread, long-lasting consequences on brain physiology, most of which are only partially understood. The complexity of these plastic events makes it difficult to efficiently care for patients, and current treatments have little power to avoid relapse. The transition from drug use to addiction [3] occurs gradually and involves both neuro- and synaptic plasticity These long-lasting adaptive changes persist even after withdrawal of the drug, and they are likely to underlie the persistent tendency to relapse [4]. In models as varied as human post-mortem brains from cocaine abusers and mice or rats of different genetic backgrounds, changes related to molecular pathways controlling neurotransmitter signaling (including a downregulation of the dopamine D2 receptor), signal transduction, ion-gated channel activity, cytoskeletal structures, extracellular matrix remodeling, synaptogenesis, axonal dynamics and cell metabolism [6,7,8] (reviewed in [9,10]) have been identified
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
