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Abstract
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark conditions, following the development of a swim bladder at 4 days post fertilization. This swimming behavior is increasingly employed in the screening of neuroactive drugs. The recent emergence of high-throughput techniques for the automatic tracking of zebrafish larvae has further allowed an objective and efficient way of finding subtle behavioral changes that could go unnoticed during manual observations. This review highlights the use of zebrafish larvae as a high-throughput behavioral model for the screening of neuroactive compounds. We describe, in brief, the behavior repertoire of zebrafish larvae. Then, we focus on the utilization of light-dark locomotion test in identifying and screening of neuroactive compounds.
Highlights
There are many practical advantages of using zebrafish as an animal model such as external fertilization, optical transparency, small size, high fecundity, and low housing cost [1,2,3]
In brief, the behavior repertoire of zebrafish larvae and discuss the utility and importance of light and dark stimuli-induced locomotor behavior in identifying neuroactive compounds
Using d-amphetamine, cocaine, and ethanol, Irons et al showed that zebrafish larvae are sensitive to neuroactive drugs and their locomotor response is like that of mammals [83]
Summary
There are many practical advantages of using zebrafish as an animal model such as external fertilization, optical transparency, small size, high fecundity, and low housing cost [1,2,3]. Zebrafish larvae after 4 dpf, when exposed to an alternating light and dark stimuli, create a pattern of increased movement in the dark followed by resting state in the light [29]. This behavior has been increasingly utilized in the high-throughput screening of various neuroactive drugs recently. This review focuses on the light and dark stimuli-induced locomotor behavior of zebrafish larvae as a behavioral model to study neuroactive compounds. In brief, the behavior repertoire of zebrafish larvae and discuss the utility and importance of light and dark stimuli-induced locomotor behavior in identifying neuroactive compounds. We discuss the recent progress made in behavioral research in the context of the emergence of various high-throughput techniques for the automatic tracking of larvae
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