Abstract
Zebrafish (Danio rerio) is a relevant model for studying many diseases, including the melanocyte-related disorders. In this review of melanocyte literature, we discuss current knowledge about different forms of albinism and the potential of the zebrafish model to find new mechanisms and treatments. Melanin is produced in a process called melanogenesis. This, if altered, leads to diseases such as albinism. Albinism causes an increased risk of skin cancer. Zebrafish are used to study pigment disorders, due to their high fecundity, visible development of melanin in melanophores (melanocytes in mammals) from 24 h post-fertilization, and preserved melanogenesis pathways. In this case, we looked for developmental pathways in zebrafish melanophores and mammalian melanocytes. In addition, we summarized advances in understanding pigment cell disease and evidence supporting the potent potential of using zebrafish to better understand the management of albinism
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Annals of the Academy of Romanian Scientists Series on Biological Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.