Zebrafish as a model for Rhabdovirus infection and molecular mechanism of the immune response

Abstract

Rhabdovirus is one of the most important pathogens causing fish viral infections. The Rhabdovirus infection on animal zebrafish ( Danio rerio ) model and its mechanism of the immune response have been investigated in recent years. However, no systematic review has been reported on Rhabdovirus infected zebrafish model. The recent studies showed that Toll-like receptor (TLRs) or RIG-I like receptor (RLRs)-mediated interferon (IFNs) reaction and complement pathway were activated, and mitogen activated protein kinase (MAPKs), myeloid differentiation factor 88 (MyD88)/nuclear factor kappa B (NF-κB) were involved in the molecular regulation of immune responses in zebrafish. In this study, zebrafish as a model for Rhabdovirus infection and molecular mechanism of the immune response were reviewed, including zebrafish infected with the rhabdovirus such as SVCV, VHSV, IHNV and SHRV, respectively. This study firstly focuses on the molecular mechanism of the zebrafish immune response and research progress, which will provide a scientific reference to prevention and treatment of rhabdovirus diseases in fish.