Zašto topikalni kortikosteroid plus antibiotik?

Abstract

Numerous dermatoses can be treated (at least in certain phases of the disease) exclusively with local therapy. Although there is a large number of dermatological diseases, therapeutic options for local therapy are not numerous. However, adequate and timely application of available topical preparations and their combination, enables a large number of different dermatoses to be treated with a relatively small number of topical preparations. The framework of local dermatological therapy and the most commonly prescribed preparations are corticosteroids. Topical corticosteroids are used to treat inflammatory dermatoses, while they are not recommended for use in acne vulgaris, fungal and bacterial skin infections. Designing preparations that contain a topical corticosteroid and antimycotic, corticosteroid and antibiotic, and sometimes all three substances, enables the use of corticosteroids in the above-mentioned infectious skin diseases. Topically applied antibiotics play a significant role in the treatment of mild forms of acne vulgares, while in localized bacterial skin infections, their importance is such that they often make general antibiotic therapy-unnecessary. Topical corticosteroids are most often combined with oxytetracycline, bacitracin and aminoglycosides - gentamicin and neomycin. The combination of betamethasone and gentamicin in a topical preparation is often used in everyday medical practice. It is recommended for many skin diseases in which betamethasone acts anti-inflammatory, immunosuppressive, vasoconstrictive, reducing erythema, edema and skin inflammation, while gentamicin acts on gram-positive and negative bacteria that are sensitive to it and are present on the surface of affected lesions due to superinfection. Since betamethasone is a potent corticosteroid with a good effect on a large number of dermatoses and gentamicin has antibiotic and anti-inflammatory properties and effect, the combined preparation of betamethasone - gentamicin is an excellent and rational solution in local therapy of many dermatoses.