Abstract
New manzamine alkaloids, zamamidine C ( 1), 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A ( 2), and 3,4-dihydromanzamine J N-oxide ( 3), have been isolated from an Okinawan marine sponge Amphimedon species. The structures and stereochemistries of 1– 3 were elucidated from the spectroscopic data and chemical derivatization. Zamamidine C ( 1) is a new manzamine alkaloid possessing a second β-carboline ring via an ethylene unit at N-2 of manzamine D, while 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A ( 2) is the first manzamine alkaloid possessing an epoxide ring at C-10 and C-11. Zamamidine C ( 1) showed significant antitrypanosomal activity against Trypanosoma brucei brucei, the parasite associated with sleeping sickness, and antimalarial activity against Plasmodium falciparum, the causative agent of malaria in vitro.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.