Abstract
The title compound (1-OCH3-NOTA) is a potent aldose reductase (AR) inhibitor. It is found to cocrystallize with the solvent dimethyl sulfoxide (DMSO), i.e. C17H13NO4S2.C2H6OS. The skeleton of 1-OCH3-NOTA is highly planar, except for the acetic acid group and the methoxy substituent. This particular conformation confers on this molecule an optimum geometrical complement to the shape of the aldose reductase (AR) active pocket. Molecules of 1-OCH3-NOTA, related by a centre of symmetry in the crystal structure of the DMSO solvate, are held together by van der Waals and ring-to-ring interactions. The stability of the crystal is enhanced by a hydrogen bond which links the DMSO molecule to 1-OCH3-NOTA through its carboxyl group.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Acta Crystallographica Section C Crystal Structure Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
