Abstract

Reaction of 4,5-dichloro-1,2,3-dithiazolium chloride with 2-[amino(methylthio)methylene])malononitrile (1 equiv) in the presence of pyridine (2 equiv) gave (Z)-2-{[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino](methylthio)methylene}malononitrile in 20% yield. The compound was fully characterized.

Highlights

  • Isothiazoles are isomers of thiazoles that find uses in the medicinal (e.g., antirhinovi-Citation: Kalogirou, A.S.; Koutentis, P.A. (Z)-2-(((4-chloro-5H-1,2,3Citation: dithiazol-5-ylidene)amino) P.A.(Z)-2-{[(4-Chloro-5H-1,2,3(methylthio)methylene)malonodithiazol-5-ylidene)amino]nitrile

  • Another interesting synthesis of isothiazoles 6 directly from Appel’s salt 7 and primary enamines was reported by Rees [28]

  • The reaction mixture was monitored by TLC using commercial glass backed thin layer chromatography (TLC) plates (Merck Kieselgel 60 F254 )

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Summary

Introduction

Isothiazoles are isomers of thiazoles that find uses in the medicinal

Methods
Results
Conclusion
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