Abstract
Objective: to study the cytotoxic activity of the zinc (II) and cadmium (II) iodide complexes with antipyrine (AP), caffeine (caf) and 1,10-phenantroline (phen) in comparison with that of free ligands, zinc (II) and cadmium (II) iodides in vitro. Materials and methods. The cytotoxic activity of the zinc (II) and cadmium (II) iodide complexes with AP, caf and phen in comparison with that of free ligands, zinc (II) and cadmium (II) iodides was investigated by methylthiazole tetrazolium assay using 5 human tumor cell lines. Results. It has been found that all 3 cadmium complexes demonstrate cytotoxic activity towards all 5 cell lines with concentration of inhibition of 50 % cell growth 5.5-84.0 mkM. Cytotoxicity of the most active diiodo(1,10-phenantroline)cadmium was slightly above than that of the respective ligand. One zinc-containing complex (diiodo(1,10-phenantroline)zinc) demonstrated significant activity towards 3 cell lines. The Jurkat cells were the most sensitive to studied compounds. Conclusion. It seems that zinc (II) and cadmium (II) iodide complexes with organic ligands are promising ones as potential antitumor drugs for further investigations both in vitro and in vivo.
Highlights
The cytotoxic activity of the zinc (II) and cadmium (II) iodide complexes with AP, caf and phen in comparison with that of free ligands, zinc (II) and cadmium (II) iodides was investigated by methylthiazole tetrazolium assay using 5 human tumor cell lines
It has been found that all 3 cadmium complexes demonstrate cytotoxic activity towards all 5 cell lines with concentration of inhibition of 50 % cell growth 5.5–84.0 mkM
It seems that zinc (II) and cadmium (II) iodide complexes with organic ligands are promising ones as potential antitumor drugs for further investigations both in vitro and in vivo
Summary
Цитотоксическая активность комплексов иодидов цинка и кадмия с антипирином, кофеином и фенантролином. Цель работы – исследование цитотоксической активности in vitro комплексов иодидов цинка и кадмия с органическими лигандами – антипирином (AP), кофеином (caf) и 1,10-фенантролином (phen) – в сравнении с исходными соединениями: незакомплексованными лигандами, а также иодидами цинка (II) и кадмия (II). Objective: to study the cytotoxic activity of the zinc (II) and cadmium (II) iodide complexes with antipyrine (AP), caffeine (caf) and 1,10-phenantroline (phen) in comparison with that of free ligands, zinc (II) and cadmium (II) iodides in vitro. The cytotoxic activity of the zinc (II) and cadmium (II) iodide complexes with AP, caf and phen in comparison with that of free ligands, zinc (II) and cadmium (II) iodides was investigated by methylthiazole tetrazolium assay using 5 human tumor cell lines. Комплексные соединения переходных металлов перспективны как потенциальные противоопухолевые препараты широкого спектра действия
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
