You Are What You Eat: Impact of Early Metabolic Syndrome on Long-Term Outcome after Heart Transplantation

Abstract

Purpose Metabolic syndrome (MS) is seen in a high rate of heart transplant patients. In recent studies MS has been associated with long-term complications. The aim of this analysis was to evaluate the impact of MS on long-term outcome after heart transplantation. Methods and Materials 307 adult one-year survivors after heart transplantation were analysed between 1997-2009. All had a BMI Results 121 (39.4%) patients developed MS during the first 12 months after transplantation. 5- and 10-year survival was significantly lower in Group I (5 years: 85.1% vs. 95.1%; p=0.002; 10 years: 70% vs. 81.1%; p=0.006) Patients in group I had a higher rate of death from of cancer (7% vs. 1.6%; p=0.032) and CAV (8.3% vs 2.7%; p=0.014) Group 1 had a significantly higher rate of severe CAV (45% vs. 20%; p=0,008) A Body mass index ≥ 25 before HTX (30% vs. 51%; p 35a (20% vs. 41.5% p=0.022) were associated with a higher risk to develop MS Syndrome during the first year after HTX. Conclusions Development of MS during the first year after transplantation is a significant risk factor for Long-term survival and CAV development. Higher age and BMI at the time of transplant are associated with a higher risk to develop MS. Mechanisms of intervention a strongly needed to counteract.