Abstract

Yolk sac tumor (YST), which most frequently arises in the gonads as a type of germ cell tumor, is rare in children but is highly malignant. The common age group affected by yolk sac tumours is 11 to 24 years. In this study, we described a rare case of YST in terms of the clinical manifestation, imaging, and histopathology findings, diagnosis and treatment in a 12-year-old girl who was followed since birth for Fanconi-like syndrome. This is a rare clinical association that also limits chemotherapy.

Highlights

  • The association of malformative abnormalities and cancer is known in several situations: such as Wiedeman-Beckwith syndrome, neurofibromatosis type 1, defect in DNA repair, Drash syndrome and WAGAR syndrome Wilms tumor, aniridia, genitourinary anomalies, and intellectual disability genitourinary anomalies, and intellectual disability)

  • Yolk sac tumor (YST), which most frequently arises in the gonads as a type of germ cell tumor, is rare in children but is highly malignant

  • We described a rare case of YST in terms of the clinical manifestation, imaging, and histopathology findings, diagnosis and treatment in a 12-year-old girl who was followed since birth for Fanconi-like syndrome

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Summary

Introduction

The association of malformative abnormalities and cancer is known in several situations: such as Wiedeman-Beckwith syndrome, neurofibromatosis type 1, defect in DNA repair, Drash syndrome and WAGAR syndrome Wilms tumor, aniridia, genitourinary anomalies, and intellectual disability genitourinary anomalies, and intellectual disability). Several other associations remain unexplained, and the fortuitous or significant character is not always obvious. Fanconi-like syndrome is a genetic abnormality characterized by chromosomal instability responsible for the malformation syndrome.

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