Abstract

We have found that a single dose of amitraz, a formamidine pesticide, produces death in mice 2–5 days after dosing. To further examine this phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg kg , i.p.) or deionized water (6 ml kg , i.p.), immediately before an injection of amitraz (600 mg kg , i.p.) and twice daily thereafter for 8 days. Male mice treated with water were more susceptible than water-treated females to the lethal effects of amitraz. In addition, yohimbine treatment significantly decreased the number of deaths in both sexes. These data suggest that an α2-adrenergic mechanism is involved in the delayed lethality produced by amitraz. This manuscript has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Mention of trade names and commercial products does not constitute endorsement or recommendation for use.

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