Ykl-40 and cancer antigen 72-4 as new and promising diagnostic and prognostic markers for endometrial cancer

Suat Karataş,Macit Arvas,Nigar Sofiyeva,Fuat Demirkıran,Onur Güralp,İlker Kahramanoğlu,Veysel Şal,Hafize Uzun,Tugan Beşe

doi:10.4274/tjod.77906

Abstract

Objective:To determine the predictive role of serum levels of YKL-40 and cancer antigen (CA) 72-4 in the diagnosis of endometrial cancer (EC).Materials and Methods:Forty-one patients with EC and 21 women with uterine polyps were evaluated between January and December 2015 in a prospective study.Results:Age, body mass index, preoperative serum YKL-40 and CA 72-4 levels were significantly higher in the malignant group compared with the control group. Serum YKL-40 levels were significantly higher in patients with superficial myometrial invasion and no lymph node involvement (p=0.042; p=0.004). No relationship between clinicopathologic factors and serum CA 72-4 levels was found.Conclusion:Serum CA 72-4 and YKL-40 levels are increased in women with EC compared with uterine polyps. Preoperative serum YKL-40 levels may be associated with favorable prognostic factors. The determination of YKL-40 before surgery may be helpful in the evaluation of the regional lymph nodes.

Highlights

Abnormal uterine bleeding is the initial symptom in 75 to 90% of the patients with endometrial carcinoma (EC)
Age, body mass index, preoperative serum YKL-40 and cancer antigen (CA) 72-4 levels were significantly higher in the malignant group compared with the control group
Preoperative serum YKL-40 levels may be associated with favorable prognostic factors

Summary

Introduction

Abnormal uterine bleeding is the initial symptom in 75 to 90% of the patients with endometrial carcinoma (EC). Tumor markers have been widely investigated in order to detect EC during early phases and to monitor the disease. Serum human epididymis protein (HE)-4 levels were significantly higher in patients with recurrent EC. HE-4 was likely to be superior to CA-125 in detecting recurrent EC[5] Both of these markers are significantly correlated with higher histologic grade, stage, lymph node metastases, myometrial invasion, and cervical involvement in patients with EC[6,7,8].YKL-40 (Human Chitinase-3-like protein 1) is a glycoprotein that belongs to the chitinase family. Our objective was to determine the efficacy of YKL-40 and CA724 in the early diagnosis of EC and to evaluate whether both markers had prognostic value for EC

Methods

Results

Discussion

Conclusion