Abstract
GABAB receptors are expressed in the ventral tegmental area (VTA), the origin of the dopamine (DA) reward system. Activation of GABAB receptors has been shown to reduce the firing of VTA DA neurons and attenuate rewarding effects of several addictive substances. Therefore, agonists of GABAB receptors are being proposed as a potential universal anti-abuse therapy because of their impact against multiple addictive substances. Despite …
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