Yenidoğan Yoğun Bakım Ünitemizdeki Erken ve Geç Trombositopeni Nedenlerinin Değerlendirilmesi

Abstract

Aim : Thrombocytopenia is a common hematologic problem in the neonatal period. The aim of the study is determine of prevalence and reasons of thrombocytopenia in patients in our newborn intensive care unit (NICU). Material and Methods : Medical records of patients who were hospitalized in NICU between January 2011 and May 2014 were inspected retrospectively. Early thrombocytopenia was identified as thrombocytopenia developing within first 72h’s of life and late thrombocytopenia was identified as thrombocytopenia developing after the first 72h’s of life. Demographic characteristics, clinical and laboratory parameters of the patients’ were recorded. Results: The prevalence of thrombocytopenia was 11% in the study period. The reasons of early thrombocytopenia were placental insufficiency (n=14), with one patient having accompanying chromosomal anomaly, sepsis (n=14), maternal thrombocytopenia (n=7), perinatal asphyxia (n=6), and hemophagocytic syndrome (n=1). Pseudothrombocytopenia and neonatal alloimmune thrombocytopenia was considered in two and four patients respectively. The reasons of late thrombocytopenia were culture proven sepsis (n=15), clinical sepsis (n=10), necrotizing enterocolitis (n=7), TAR Syndrome (n=1), CMV infection (n=1), and pseudothrombocytopenia (n=5). Conclusion: In our study we showed that early thrombocytopenia is related to prenatal or natal complications, however late thrombocytopenia is related to late onset infection or necrotizing enterocolitis. In conclusion, the time of onset of thrombocytopenia is important to determine the etiology of thrombocytopenia. Key Words: Thrombocytopenia, newborn, sepsis