Yellow fever vaccine-associated viscerotropic disease in a young patient evolving to death: a case report

Abstract

This article reports a case of yellow fever vaccine-associated viscerotropic disease (YEL-AVD). Case presentation: A 26-year-old woman, with a history of recent vaccination for yellow fever, was hospitalized for investigation of febrile syndrome, evolving with significant thrombocytopenia and acute kidney injury, requiring intensive care on the third day in the hospital. Despite the care, she died three days after being admitted to the ICU. Liver immunohistochemistry and serology for IgM were, respectively, positive and reactive for the yellow fever virus. In addition, RT-PCR of collected samples confirmed the vaccination origin of the strain.