Abstract
TFIID comprises the TATA box–binding protein and a set of highly conserved associated factors (TAFIIs). yTAFII145, the core subunit of the yeast TAFII complex, is dispensable for transcription of most yeast genes but specifically required for progression through G1/S. Here we show that transcription of G1 and certain B-type cyclin genes is dependent upon yTAFII145. At high cell density or following nutrient deprivation, yeast cells cease division, enter a G0-like state, and terminate transcription of most genes. In this stationary phase, we find that the levels of yTAFII145, several other yTAFIIs, and TBP are drastically reduced. Collectively, our results indicate that yTAFII145 and other TFIID components have a specialized role in transcriptional regulation of cell cycle progression and growth control.
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