Abstract
In yeast, basic fuchsin both inhibits mitochondrial functions and is a potent mutagen for the mitochondrial genome. A genetic analysis of two mutants resistant to the dye indicate that: (1) resistance is specified by a nuclear gene; (2) the onset of resistance in sensitive cells is controlled by the mitochondiral genome; and (3) sensitive mitochondrial structures can be carried over for many cell generations in the presence of a resistant nuclear genotype.
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Schedule a callMore From: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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