Abstract
The mating-type locus (MAT) in the yeast Saccharomyces cerevisiae provides information about whether cells are of the a or α mating type, and genes at this locus encode transcriptional regulators that determine the phenotypes associated with the different cell types1. In a/α diploid cells, the a1/α2 repressor is formed, which inhibits haploid-specific gene expression and indirectly promotes meiosis. Mutations in SIR (silent information regulator) genes cause a loss of both heterochromatin and transcriptional silencing, resulting in the expression of cryptic a and α genes resident at the HML and HMR loci. As a result, sir mutant strains have the properties of a/α diploids.
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