Abstract
Today’s biotechnologists seek new biocatalysts to meet the growing demand for the bioproducts. This review critically evaluates the potential use of Y. lipolytica as an oleaginous cell factory platform. This yeast has undergone extensive modifications for converting a wide range of hydrophobic and hydrophilic biomass, including alkane, oil, glycerol and sugars to fatty acid-based products. This article highlights challenges in the development of this platform and provides an overview of strategies to enhance its potential in the sustainable production of biodiesel, functional dietary lipid compounds and other value-added oleochemical compounds. Future applications of the recombinant Y. lipolytica platform are also discussed.
Highlights
The development of sustainable microbial platforms for chemical and fuel production is becoming even more crucial as petroleum reserves are depleted and environmental problems increase throughout the world
Yarrowia lipolytica provides a promising platform to produce a wide range of lipid-based bioproducts
Further exploration on regulatory and transport mechanisms, transcriptional machinery, and signal transduction pathways, involved in lipid accumulation and degradation will pave the way to better understanding and utilization of this platform
Summary
Bioprocessing and Bioproducts Engineering Laboratory, Department of Biological Systems Engineering, Washington State University, Pullman, WA, USA. Edited by: Lew Paul Christopher, South Dakota School of Mines and Technology, USA. Chinese Academy of Sciences, China Biplab Kumar Debnath, Politecnico di Torino, Italy Yu-Shen Cheng, University of California Davis, USA. Today’s biotechnologists seek new biocatalysts to meet the growing demand for the bioproducts. This review critically evaluates the potential use of Y. lipolytica as an oleaginous cell factory platform. This yeast has undergone extensive modifications for converting a wide range of hydrophobic and hydrophilic biomass, including alkane, oil, glycerol, and sugars to fatty acid-based products.
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