Abstract

Overexpression of the Hippo pathway-regulated transcriptional co-activator Yes-Associated Protein (YAP) is frequently detected in human hepatocellular carcinoma (HCC) and correlates with poor clinical outcome of cancer patients [1]. So far YAP is associated with the stimulation of single pro-tumorigenic target genes such as FoxM1 and CTGF [2]. However, if YAP also coordinates the expression of functionally related protein families, is unknown.

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