Abstract
Development Lung morphogenesis is a complex process involving rearrangements of various cell types to achieve the branched patterning necessary to maximize gaseous exchange. Lin et al. found that YAP, a component of the Hippo pathway known to be important for organ size regulation, is required for branching. YAP is expressed throughout the murine lung epithelium. Local inhibition of YAP decreases local cell proliferation, which means inadequate force is produced to move cells and form airway branches. Genomic analysis showed that YAP regulates levels of pMLC (phosphorylated myosin light chain), which is required for cells to produce mechanical force. The YAP mechanism may also be involved in branching in other tissues. eLife 10.7554/eLife.21130 (2017). ![Figure][1] Regulation of motor proteins forces developing tissues to branch. PHOTO: BIOPHOTO ASSOCIATES/SCIENCE SOURCE [1]: pending:yes
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.