Yaşlılarda Levofloksasin Kullanımının Güvenliliği

Abstract

Aim: Levofloxacin is one of the most prescribed antibacterial agents. They are used for the treatment of many infections, which are of paramount importance for geriatric practice. In this study, we aimed to investigate the safety of levofloxacin, which provides many advantages in older patients. Material and Methods: The medical records of 92 older patients admitted to the geriatric clinic and treated with levofloxacin for any reason were retrospectively reviewed. Demographic characteristics, drugs, electrocardiography parameters, Apathy Evaluation Scale score, and delirium evaluated by Confusion Assessment Method were recorded on the baseline and the third day. We also recorded 21 patients’ seventh-day data, which can be available. All the patients or caregivers were questioned about tendinitis or tendon rupture within 90 days after treatment at the outpatient controls. Results: The mean age of the patients was 80.75±7.01 years, and 57.6% were female. There was a significant difference between baseline and third day QT (p:0.008) and QTc (p<0.001) values, but on the 7th day, not (p>0.05). Delirium and Apathy Evaluation Scale scores improved during the treatment (p>0.05). No patient had a seizure. Tendinitis and tendon rupture were not detected during or within the three months after the treatment. Conclusion: In the light of these results, the use of levofloxacin seems to be safe in older adults, with caution on additional risk factors.