Abstract
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse, although the literature hardly offers any molecular mechanisms governing their activities in the cell, tissue, or the whole organism. This review describes the involvement of YB proteins in RNA-dependent processes, such as mRNA packaging into mRNPs, mRNA translation, and mRNA stabilization. In addition, recent data on the structural peculiarities of YB proteins underlying their interactions with nucleic acids are discussed.
Highlights
Y-box binding proteins (YB proteins) were first identified as DNA-binding proteins involved in the regulation of transcription in various organisms [1]; their major property was thought to be the ability to bind to double-stranded DNAs containing the so-called Y-box motif
Since one review can hardly cover all the proven and alleged roles of YB proteins in a cell or the whole organism, here we focus on peculiar interactions of these proteins with RNAs and their involvement in RNA-dependent processes, such as mRNA packaging into messenger ribonucleoprotein particles (mRNPs), mRNA translation, and mRNA stabilization
The RIP-Seq (RNA Immunoprecipitation Sequencing) analysis showed that in HEK293T cells, the mRNA sets bound to YB-1 and YB-3 are almost the same, and they amount to about 80% of the transcriptome [79]
Summary
Y-box binding proteins (YB proteins) were first identified as DNA-binding proteins involved in the regulation of transcription in various organisms [1]; their major property was thought to be the ability to bind to double-stranded DNAs containing the so-called Y-box motif. These proteins are known to be studied previously as major universal components of messenger ribonucleoprotein particles (mRNPs) in various organisms and cells. Ttohias deifnfearteunrceedissttahtoeuigsh3t5to◦Cb,ewduheerteoaasltohnagt of mobile loop in the YB-1 cold shock domain and a short one in prokaryotic proteins. TThhee eeffffeecctt ooff GGllNNAAcc--TThhrr112266 oonn SSeerr110022 pphhoosspphhoorryyllaattiioonn iiss rreepprreesseenntteedd
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