Abstract
Thermoreversible gels formed by a xyloglucan polysaccharide derived from tamarind seed were evaluated as a sustained-release vehicle for the intraperitoneal administration of mitomycin C (MMC). The in vitro release of MMC from gels prepared from galactoxyloglucan that had been partially degraded by β-galactosidase to eliminate 44% of galactose residues followed root-time kinetics over 5 h. Intraperitoneal administration of MMC in a 1.5% (w/w) xyloglucan gel to rats resulted in a broad concentration–time profile for this drug in both the ascites and the plasma over a 3-h time period, compared with a narrow peak and rapid disappearance from both sites when this drug was given i.p. as a solution.
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