Abstract
Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC50 values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively.Graphical
Highlights
Actinomycetes are well-known for their ability to produce natural products with structural complexity and diverse biological activities [1, 2]
The investigation of secondary metabolites from the Promicromonospora xylanilytica YIM 61515 led to the discovery of three new products, xylanilyticolides A–C (1–3) (Fig. 1) [9]
Their structures were elucidated by analyses of 1D and 2D NMR spectroscopic methods
Summary
Actinomycetes are well-known for their ability to produce natural products with structural complexity and diverse biological activities [1, 2]. The investigation of secondary metabolites from the Promicromonospora xylanilytica YIM 61515 led to the discovery of three new products, xylanilyticolides A–C (1–3) (Fig. 1) [9]. Their structures were elucidated by analyses of 1D and 2D NMR spectroscopic methods. Their cytotoxicities against five human cancer cell lines were evaluated. Report are the isolation, structural elucidation and cytotoxicities of them
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