Xuefu Zhuyu Decoction on Heart Failure Patients with Middle-Range Coronary Heart Disease with Ejection Fraction

Abstract

To investigate the impact of Xuefu Zhuyu decoction on cardiac remodeling and quality of life of patients with heart failure and middle-range coronary heart disease with ejection fraction is the main objective of the study. 116 heart failure patients with coronary heart disease in the middle range of ejection fraction were divided as observation or control group. Clinical efficacy of both groups was observed and changes in traditional Chinese medicine symptom scores, cardiac function classification, exercise tolerance, cardiac ultrasound indexes and quality of life were compared before and after treatment between both groups. Relative to before treatment, left ventricular ejection fraction of two groups enhanced dramatically (p<0.05) and the left ventricular enddiastolic diameter increased significantly (p<0.05). Serum N-terminal pro-B-type natriuretic peptide and left ventricular end-systolic diameter significantly declined (p<0.05). Relative to before treatment, physical limitation, physical condition, emotional change, social limitation score and total score in each dimension of Minnesota living with heart failure questionnaire scale obviously declined in both groups (p<0.05), compared with control group following treatment. The above scores decreased in observation group relative to control group (p<0.05). Xuefu Zhuyu decoction can significantly enhance cardiac function and exercise tolerance of such cases, inhibit or reverse cardiac remodeling, and be beneficial to the improvement of quality of life.