Abstract
BackgroundIn the X-ray repair cross-complementing group 1 (XRCC1) gene, a polymorphism, Arg399Gln (rs25487), has been shown to change neoconservative amino acid and thus result in alternation of DNA repair capacity. Numerous studies have investigated the association between Arg399Gln and breast cancer risk in the American population, but yielding inconsistent results. This study aimed to clarify the role of this polymorphism in susceptibility to breast cancer.MethodsLiteratures were searched in multiple databases including PubMed, Springer Link, Ovid, EBSCO and ScienceDirect databases up to April 2013. A comprehensive meta-analysis was conducted to estimate the overall odds ratio (OR), by integrating data from 18 case control studies of 10846 cases and 11723 controls in the American population.ResultsOverall, significant association was observed between the Arg399Gln polymorphism and breast cancer risk under the random-effects model (OR for dominant model = 1.12, 95% CI: 1.02–1.24, P heterogeneity = 0.003; OR for additive model = 1.07, 95% CI: 1.01–1.14, P heterogeneity = 0.017). Further sensitivity analysis supported the robust stability of this current result by showing similar ORs before and after removal of a single study.ConclusionsThis meta-analysis suggests that the XRCC1 Arg399Gln polymorphism may significantly contribute to susceptibility of breast cancer in the American population.
Highlights
Breast cancer is the most common cancer and a predominate cause of cancer related-death in female population worldwide [1]
Duell et al suggested that the variant of Arg399Gln might confer increased risk of breast cancer [12], whereas Dawei Bu et al reported no association of this polymorphism and breast cancer [18]
Literature Search Relevant articles published before April 1st, 2013 were identified through a electronically search in the PubMed, Springer Link, Ovid, EBSCO and ScienceDirect databases using the combination of key words: ‘X-ray repair cross-complementing group 1 (XRCC1)’, ‘polymorphism’, ‘Arg399Gln’, ‘SNP’, ‘variant’, ‘BC’ and ‘breast cancer’
Summary
Breast cancer is the most common cancer and a predominate cause of cancer related-death in female population worldwide [1]. Multiple studies have been conducted to explore the association of this polymorphism and the disease risk in the USA [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26]; results were inconsistent. Based on previously published studies, four meta-analysis have been conducted on the Arg399Gln and breast cancer risk [27,28,29,30], but not special in the American population. We believed that it is essential to conduct an update comprehensive meta-analysis including studies published since 2001 to provide a more precise assessment of the association between the Arg399Gln in XRCC1 and breast cancer risk in the American population. This study aimed to clarify the role of this polymorphism in susceptibility to breast cancer
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