Abstract
BackgroundA lot of studies have investigated the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk, but the results in Asian population were still inconclusive. We conducted a meta-analysis to ascertain the association of XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms with bladder cancer risk in Asian population.Methodology/Principal findingsThe association strength was measured with odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of 9 eligible studies, conducted in China, India and Japan, were identified. We observed a significant increased risk of bladder cancer in dominant model (OR = 1.199, 95% CI: 1.021,1.408, Pheterogeneity = 0.372), allele comparison (OR = 1.200, 95% CI: 1.057,1.362, Pheterogeneity = 0.107) of Arg194Trp, heterozygote comparison (OR = 1.869, 95% CI: 1.205,2.898, Pheterogeneity = 0.011) and dominant model (OR = 1.748, 95% CI: 1.054,2.900, Pheterogeneity = 0.01) of Arg280His. Pooled results estimated from adjusted ORs further validated these findings. No publication bias was detected. Subgroup analyses found that significant increased risk was only found among community-based studies not hospital-based studies. There was no evidence of publication bias.ConclusionThis is the first meta-analysis conducted in Asian investigating the correlation between XRCC1 polymorphisms and susceptibility to bladder cancer. Our meta-analysis shows that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with a significantly increased risk of bladder cancer in Asian population.
Highlights
Urinary bladder cancer is the sixth most common cancer, accounting for 14880 cases in the United States in 2012 [1], and the tenth in China [2]
This is the first meta-analysis conducted in Asian investigating the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and susceptibility to bladder cancer
Our meta-analysis shows that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with a significantly increased risk of bladder cancer in Asian population
Summary
Urinary bladder cancer is the sixth most common cancer, accounting for 14880 cases in the United States in 2012 [1], and the tenth in China [2]. Tobacco smoking and occupational exposure to certain chemical carcinogens have been established as the major risk factors of bladder cancer [3]. These carcinogens can cause DNA damage [4], and unrepaired DNA damages will lead to mutations and cancers [5]. Polymorphisms of x-ray cross complementing group 1 (XRCC1), a gene involved in the DNA base excision repair (BER) pathway, have been suspected with bladder cancer risk for decades. A lot of studies have investigated the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk, but the results in Asian population were still inconclusive. We conducted a metaanalysis to ascertain the association of XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms with bladder cancer risk in Asian population
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