Abstract
The x-ray holography program at the Lawrence Livermore National Laboratory has two principal goals: the development of x-ray diffraction techniques for DNA sequence analysis and the development of x-ray laser holography for structural analysis of intact biological cells and organelles. DNA sequence analysis will be accomplished via x-ray diffraction techniques to determine the ensemble average of the sequence of labels along the individual elements of crystalline DNA. X-ray laser holographic imaging will be accomplished via 3-D x-ray holography to elucidate the structure of few hundred angstrom objects such as 300 Å chromatin fibers, nuclear pores and nucleic acid replication complexes in living cells. Existing laboratory x-ray lasers will be used to produce flash x-ray holograms of the biological structures.
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