Abstract
Xeroderma pigmentosum group G (XPG), a key component in nucleotide excision repair pathway, functions to cut DNA lesions during DNA repair. Genetic variations that alter DNA repair gene expression or function may decrease DNA repair ability and impair genome integrity, thereby predisposing to cancer. The association between XPG rs17655 G>C polymorphism and cancer risk has been investigated extensively, but the results remain contradictory. To get a more accurate conclusion, we performed a comprehensive meta-analysis of 60 case-control studies, involving 27,098 cancer cases and 30,535 healthy controls. Crude odds ratios (ORs) and 95% confidence interval (CIs) were calculated to determine the association of interest. Pooled analysis indicated that the XPG rs17655 G>C polymorphism increased the risk of overall cancer (CC vs. GG: OR=1.10, 95% CI=1.00-1.20; CG vs. GG: OR=1.06, 95% CI=1.02-1.11; CG+CC vs. GG: OR=1.07, 95% CI=1.02-1.12; C vs. G: OR=1.05, 95% CI=1.01-1.09). Stratification analysis by cancer type further showed that this polymorphism was associated with increased risk of gastric cancer and colorectal cancer. This meta-analysis indicated that the XPG gene rs17655 G>C polymorphism was associated with increased overall cancer risk, especially the risk of gastric cancer and colorectal cancer. Further validation experiments are needed to strength our conclusion.
Highlights
Cancer-related deaths continue to rise in both developed and developing countries
After reviewing titles and abstracts, we excluded 281 publications not investigating the association between Xeroderma pigmentosum group G (XPG) gene rs17655 polymorphism and cancer risk
After calculating crude odds ratios (ORs) and 95% confidence interval (CIs), we found that XPG gene rs17655 G>C polymorphism was associated with increased overall cancer susceptibility www.aging-us.com (CC vs. GG: OR=1.10, 95% CI=1.00-1.20, P=0.032; CG vs. GG: OR=1.06, 95% CI=1.02-1.11, P=0.013; CG+CC vs. GG: OR=1.07, 95% CI=1.02-1.12, P=0.004; C vs. G: OR=1.05, 95% CI=1.01-1.09, P=0.011)
Summary
Cancer-related deaths continue to rise in both developed and developing countries. 14.1 million new cancer cases and 8.2 million cancerrelated deaths all over the world. Lung and breast cancer are the most common forms of cancer in human beings. The incidences of liver, stomach and www.aging-us.com colorectal cancer are very high in men and stomach, while cervix uteri and colorectal cancer prevail in women. A variety of cancer risk factors have been recognized, such as smoking, drinking, lack of exercise, poor diet, reproductive changes, and genetic lesions [1]. Inherited genetic causations of cancer risk are mainly unidentified. Great effects have been made to discover genetic variant alleles implicated in the crucial signaling pathways, which may influence individual cancer predisposition
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