XPC Lys939Gln(A/C)基因多态性与胃癌易感性的Meta分析

Abstract

Objective To explore the association between Xeroderma pigmentosum complementation C group (XPC) Lys939Gln (A/C) gene polymorphism and the susceptibility of gastric cancer. Methods By searching PubMed, Cochrane Library, Elsevier, Springer-Verlag, China National Knowledge Infrastructure, Chinese Biomedical Literature Data, VIP Database and Wanfang Database, all eligible case-control studies published up to September 2015 were selected and the quality of each article was valuated by two reviewers independently according to the inclusion and exclusion criteria. Meta-analysis was performed by using STATA 12.0 software. Odds ratio (OR) and 95% confidence interval (CI) were calculated. The text was estimated for the subgroup analysis, sensitivity analysis and publication bias test. Results A total of 7 case-control studies were included, including 2 336 cases with gastric cancer and 3 502 controls. The Meta-analysis showed that compared with the allele A, the allele C increased the risk of gastric cancer (OR=1.09, 95%CI: 1.01-1.18, Z=2.12, P=0.034); compared to the genotype AA, the homozygous model (CC) and dominant model (CC+ AC) also increased the risk of gastric cancer (CC vs.AA: OR=1.19, 95%CI: 1.00-1.42, Z=2.00, P=0.046; CC+ AC vs.AA: OR=1.12, 95%CI: 1.00-1.25, Z=2.03, P=0.042). The Meta-analysis showed the statistical significance between XPC Lys939Gln (A/C) gene polymorphism and the gastric cancer risk in subgroup of Asian people (C vs.A: OR=1.10, 95%CI: 1.01-1.20, Z=2.28, P=0.023; CC vs.AA: OR=1.21, 95%CI: 1.01-1.46, Z=2.02, P=0.043; CC+ AC vs.AA: OR=1.13, 95%CI: 1.01-1.27, Z=2.11, P=0.035) and the source of community in the control group (C vs.A: OR=1.11, 95%CI: 1.01-1.21, Z=2.25, P=0.024; CC vs.AA: OR=1.23, 95%CI: 1.02-1.50, Z=2.12, P=0.034). Conclusion XPC Lys939Gln(A/C) gene polymorphism may be associated with the susceptibility of gastric cancer, and genotype CC, CC+ AC and allele C can increase the risk of gastric cancer. Key words: Stomach neoplasms; Polymorphism, genetic; Polymorphism, single nucleotide; Meta-analysis; Xeroderma pigmentosum complementation C group