Abstract
The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.
Highlights
Skin cancer is the most frequent cancer in humans, especially in the Western world (Leiter et al, 2008; Gordon, 2009)
One study (Blankenburg et al, 2005) only had recessive genotype frequency, we calculated the frequency of heterozygote genotype and wild-type homozygote genotype according to the minor allele frequency (MAF) of case and control
We investigated the effect of these two xeroderma pigmentosum complementation group C gene (XPC) polymorphisms on the susceptibility to subtypes of skin cancer
Summary
Skin cancer is the most frequent cancer in humans, especially in the Western world (Leiter et al, 2008; Gordon, 2009). There are several subtypes of skin cancer: melanoma and nonmelanoma which including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) (Mueller et al, 2008). BCC and SCC are the most common types of skin cancer, and melanoma accounts for the most skin cancer deaths. Skin cancer has a complex etiology resulting from the interaction of inherited and environmental factors. Ultraviolet radiation which causes DNA damage, is considered as a major contributor to the development of skin cancer (Young, 2009). Genetic polymorphisms modulate the susceptibility to skin cancer (Meyer, 2009)
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