Abstract
Male mice received 300 R of whole body X-irradiation 4 times at 6,43, 45 and 48 weeks of age. Skin collagen was divided into 2 fractions, neutral salt soluble and insoluble collagens, by prolonged extraction of the minced skin with 1 M NaCl. The ratio of insoluble collagen to neutral salt soluble collagen was increased significantly by a total of 1200 R of whole body irradiation at 3 and 21 weeks after the last irradiation, though single 300 R did not cause any significant increase at 8 weeks after the irradiation. Not only tissue concentration but also total contents of collagen in entire lung, heart and kidney constantly increased with ageing. X-irradiation caused no significant elevation in the concentration or the total content of collagen in any of the three organs or the skin throughout the experimental pe period of 14 weeks to 65 weeks of age.
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