Abstract
XIII IMBG All-Ukrainian Conference of Young Scientists
Highlights
A large number of antibiotics are devoid of the ability of cell membrane and bacterial biofilm penetration, and intracellular short time retention, which results in inadequate intracellular distribution and low intracellular concentration [1]
The following algorithm was used to select oligonucleotide markers capable of detecting of a specific subtype of AIV: all HA, NA and NP sequences in the database were divided into groups according to certain variants of hemagglutinin (H1 and H7), neuraminidase (N1 and N9) and nucleoprotein (NP). 40 resulting groups were divided into subgroups according to the origin of the virus, which formed a consensus sequence
The number of oligonucleotides selected to determine a specific variant of HA, NA and NP depended on the number of identified conservative regions in the amplified region and on the degree of variability within the region
Summary
Hemagglutinin antigenic sites changes of pandemic influenza viruses A(H1N1)PDM09 isolated in 2009-2017 in Ukraine. ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine. SI “Gromashevsky L.V. Institute of epidemiology and infectious diseases, NAMS of Ukraine”, Kyiv, Ukraine
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