Abstract
An understanding of the cerebral circulation is so fundamental to comprehension of the pathogenesis of stroke that cerebral blood flow and metabolism merit review in this series of reports. The authors recognize that the research described here is very technical in nature and may appear to have little practical application to clinical medicine. Nevertheless, these matters are basic to the development of precise methods for the measurement of regional cerebral blood flow in man which could be used to monitor the therapy of stroke with greater success than is possible at present.
Highlights
Slil\l~IAR\' An understanding of the cerebral circulation is so fundamental lo comprehension of the pathogenesis of stroke that cerebral blood flow and metabolism merit review in this series of reports
These matters are basic to the development of precise methods for the measurement of regional cerebral blood flow in man which could be used to monitor the therapy of stroke with greater success than is possible at present
Some physicians would argue that current therapy of cerebrovascular disease is essentially unimproved over that current two or more generations ago, and that even the statistics pertaining to prophylaxis of strokes following initial warning episodes, such as transient focal ischemic attacks (TIA), are not unassailable
Summary
Slil\l~IAR\' An understanding of the cerebral circulation is so fundamental lo comprehension of the pathogenesis of stroke that cerebral blood flow and metabolism merit review in this series of reports. The conclusions reached by these investigators, using techniques primitive in comparison to the sophisticated methods available, were substantively correct, but, anticipated most of the basic concepts of CBF and CMR arrived at later by more quantitative methods They understood the role of CO., the effect of hypoxia, the role of arterial and intracranial pressure changes in the regulation of CBF, the phenomenon of autoregulation, the relative lack of influence of the sympathetic nervous system on CBF, the effects of anesthetics and many other drugs on CBF, the importance of neuron concentration in ~BF distribution, and the dependence of the brain upon glucose metabolism.
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