Abstract
Objective To observe the effects of Xiaozhong Sanyu (XZSY) pills on neurologic severity scale scores,water content and aquaporin 4 (AQP4) expression in the brain of rats after traumatic brain injury (TBI).Methods One hundred SPF-grade SD rats were randomly divided into TBI model group and XZSY intervention group (n=50); TBI models were created by Feeney free-fall impact method.XZSY pills at 20 mL/kg by gavage were given to the XZSY intervention group,and equivalent dose of distilled water was given to the TBI model group; 12 h,and 1,3,5 and 7 d after TBI,neurologic severity scale was performed,water content in the brain was measured,and immunohistochemistry was used to analyze the AQP4 expression.Results As compared with those in the TBI model group,the neurologic severity scale scores,water content and AQP4 expression in the XZSY intervention injury were significantly decreased at all observation time points (3 d:2.38±0.13 vs.2.98±0.24,82.84±0.29 vs.90.14±0.32,0.22±0.02 vs.0.25±0.03,P＜0.05).Conclusion XZSY can protect the brain tissues after TBI by reducing AQP4 protein expression and inhibiting intracellular edema. Key words: Aquaporin 4; Traumatic brain injury; Water balance; Cerebral water content
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
