XGboost-based Method for Seizure Detection in Mouse Models of Epilepsy

Abstract

Epilepsy is a chronic neurological disease which affects over 50 million people worldwide [1], caused by the disruption of the finely tuned inhibitory and excitatory balance in brain networks, manifesting clinically as seizures. Electroencephalographic (EEG) monitoring in rodent disease models of epilepsy is critical in the understanding of disease mechanisms and the development of anti-seizure drugs. However, the visual annotation of EEG traces is time-consuming, and is complicated by different models and seizure types. Automated annotation systems can help to solve these problems by reducing expert annotation time and increasing the throughput and reliability of seizure quantification. As machine learning is becoming increasingly popular for modelling sequential signals such as EEG, several researchers have tried machine learning to detect seizures in EEG traces from mouse models of epilepsy. Most existing work [2], [3] can only detect seizures in single mouse models of epilepsy and research on multiple mouse models has been limited to-date.