Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids.

Hala Al-Janaby,Richard Parsons,Haytham El-Sakka,Walimuni Ashani W Mendis,Agnieszka M Frydrych,Linda M Slack-Smith,Manal Masood

doi:10.2174/1874210601711010155

Abstract

Background:Oral lichen planus and mouth dryness are common pathoses, yet not entirely understood. These two conditions may be associated, with a few studies investigating the relationship between mouth dryness and oral lichen planus providing conflicting results. None of the studies have explored the specific impact of disease treatment on mouth dryness.Objective:The purpose of this observational before and after comparison study was to examine the effect of treatment of oral lichen planus with topical corticosteroids on mouth dryness.Methods:Nineteen subjects with oral lichen planus were evaluated for the severity of xerostomia using a xerostomia inventory and a visual analogue scale. Stimulated and unstimulated whole salivary flow rates, unstimulated salivary pH and buffering capacity were also measured. All subjects were evaluated before and after treatment with topical corticosteroids.Results:All subjects reported xerostomia before treatment with topical corticosteroids, with 79% reporting a significant improvement (P = 0.03) after treatment. Topical corticosteroid treatment was not associated with statistically significant differences in stimulated or unstimulated salivary flow rates, unstimulated salivary pH or buffering capacity.Conclusion:The results of this study suggest that treatment of oral lichen planus with topical corticosteroids may decrease the severity of dry mouth symptoms.

Highlights

Oral lichen planus (OLP) is a chronic, systemic, immunologically mediated disease, affecting about 0.1 - 2.0% of the general adult population [1 - 3]
Topical corticosteroid treatment was not associated with statistically significant differences in stimulated or unstimulated salivary flow rates, unstimulated salivary pH or buffering capacity
The results of this study suggest that treatment of oral lichen planus with topical corticosteroids may decrease the severity of dry mouth symptoms

Summary

Introduction

Oral lichen planus (OLP) is a chronic, systemic, immunologically mediated disease, affecting about 0.1 - 2.0% of the general adult population [1 - 3]. It affects men and women of all ethnic groups, women are more. The disease can occur at any age with the typical age at presentation ranging from 30-60 years [1]. The pathogenesis of this disease is not completely understood, a cell-mediated immune response appears to play a major role [4]. Oral lichen planus and mouth dryness are common pathoses, yet not entirely understood. None of the studies have explored the specific impact of disease treatment on mouth dryness

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Discussion

Conclusion