Abstract
Norman Shumway coined the aphorism that “xenotransplantation is the future of transplantation, and always will be.” In this issue of The Annals of Thoracic Surgery, Cleveland and colleagues1 from the University of Alabama give us a glimpse of this future. Nonhuman primates survived for up to 241 days after orthotopic cardiac xenotransplantation from alpha 1-3 galactosyltransferase gene knockout swine expressing human complement regulatory protein CD46 and human thrombomodulin using a clinically feasible immunosuppression regime.
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