Abstract
FK 506-binding protein (FKBP) is an immunosuppressant mediator in mammals, but its endogenous physiological function has yet to be determined. Here we report aXenopushomolog of FKBP, which is expressed at early stages of development. Injection of synthesizedXenopusFKBP mRNA, as well as murine constitutively active calcineurin, induced a secondary axis inXenopusembryos, while an FKBP mutant which does not bind to calcineurin did not. This secondary-axis-inducing effect was inhibited when FKBP was coinjected with Xmad 1 or XBMP 4 mRNA. These results suggest that FKBP modifies BMP 4 signalling by recruiting calcineurin and may have an important role in axis formation duringXenopusdevelopment.
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