Xenopus Cell Cycle Pathway for Simulating Cell Division Processes by Genomic Object Net

Abstract

To establish methods for modeling multicellular systems is the current important issues in biopathway simulations. This paper proposed a new method for modeling cell division processes with using a famous multicellular phenomenon “the changes in cell division cycles from synchronous to asynchronous in Xenopus” and succeeded in simulating this phenomenon with GON. Matsuno et al. [3] modeled and simulated a Drosophila multicellular patterning by Delta-Notch signaling pathway by using a software “Genomic Object Net” which is developed based on hybrid functional Petri net (HFPN) architecture. However, in this model, cellular formation is fixed throughout the simulation. Then, we construct an HFPN model of Xenopus cell cycle pathway which includes the mechanism for cell division control as well as checkpoint processes. With this model, dynamic cell division processes of Xenopus early embryo including the changes in cell division cycles from synchronous to asynchronous [1] are simulated.