Abstract
<DEK>Researchers’ new lung cross-circulation support system has already produced promising results Key Points •Researchers at Vanderbilt University Medical Center are maintaining human donor lungs using pigs as a bioreactor for cross-circulation. •The cross-circulation platform can maintain lungs for days and thus allow for the recovery of injured lungs. •Although pig cells and antibodies infiltrated the human lung during the study, there was no evidence of worsening lung injury. •Xenogeneic cross-circulation stands in contrast to ex vivo lung perfusion in that it provides the ability to clear toxins and metabolic waste products and provide new nutrients and metabolic inputs. •Researchers at Vanderbilt University Medical Center are maintaining human donor lungs using pigs as a bioreactor for cross-circulation. •The cross-circulation platform can maintain lungs for days and thus allow for the recovery of injured lungs. •Although pig cells and antibodies infiltrated the human lung during the study, there was no evidence of worsening lung injury. •Xenogeneic cross-circulation stands in contrast to ex vivo lung perfusion in that it provides the ability to clear toxins and metabolic waste products and provide new nutrients and metabolic inputs.
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