Abstract
Aim. To evaluate the efficiency of bone repair on a critical-sized rat calvarial defect model using our original xenogeneic bone mineral, widely established Geistlich Bio-Oss®, and autologous bone graft.Materials and Methods. We created a critical-sized calvarial defect in Sprague-Dawley rats (n = 48) and then divided them into 4 groups (unfilled defect, autologous bone graft, Geistlich BioOss® and our original xenogeneic bone mineral, 12 rats per group). Rats were sacrificed upon 4 and 12 months (6 rats per time point) with the following excision of the implant and adjacent tissues. 3D structure, extent of mineralisation, and bone volume were measured by means of microcomputed tomography. Microanatomy of the explants and adjacent tissue was investigated by haematoxylin and eosin staining.Results. The highest and the lowest bone volume was expectedly detected when the defect was filled with the autologous bone graft or remained unfilled, respectively. Replacement of the defect by the original bone mineral entailed better regeneration as compared to Geistlich Bio-Oss. Bone mineral density, bone thickness and the extent of mineralisation did not differ significantly between the experimental groups and were close to the positive control values, indicating efficient bone repair.Conclusions. Original xenogeneic bone mineral promotes induction of bone regeneration as compared to Geistlich Bio-Oss®, a commercially available bone mineral widely used in the clinical practice.
Highlights
При сравнении экспериментальных групп наблюдали больший объем новообразованной костной ткани при замещении костного дефекта оригинальным ксеногенным костным минералом в сравнении с препаратом-компаратором Geistlich Bio-Oss® (рисунок 3А)
The authors sincerely thank the staff of Mitoengineering Research Institute LLC at Moscow State University for the support in the development of an animal model and data collection
The highest and the lowest bone volume was expectedly detected when the defect was filled with the autologous bone graft or remained unfilled, respectively
Summary
При сравнении экспериментальных групп наблюдали больший объем новообразованной костной ткани при замещении костного дефекта оригинальным ксеногенным костным минералом в сравнении с препаратом-компаратором Geistlich Bio-Oss® (рисунок 3А). Сравнение показателей новообразованной костной ткани при отсутствии заполнения созданного дефекта (отрицательный контроль), а также при замещении критического дефекта костей свода черепа крыс удаленными участками теменных костей (положительный контроль) классически применяемым в хирургической практике для замещения костных дефектов препаратом Geistlich Bio-Oss® или оригинальным ксеногенным костным минералом.
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