Abstract
Introduction: Identifying the transmission clusters of multidrug-resistant A. baumannii in ICU is essential for timely intervention and control of nosocomia outbreaks. Objectives: Identify the multidrug-resistant A. baumannii transmission clusters by Next Genome Sequencing. Participants and Methods: Prospective, cross-sectional study. Study location and time: ICU of National Hospital for Tropical Diseases, from 7/2017 to 1/2018. Study subjects: samples collected from patients (putum, stool, urine and wound pus (if any)) and samples collected form the environment around the hospital beds. Results: 833 strains of A. baumannii were identified with 57 STs, of which ST2 (48%) and ST571 (24%) were predominance. The most common resistance genes were blaOXA (89.20%) and blaTEM (62.42%). 39 transmission clusters of A. baumannii were identified, involving between 2 to 22 strains, most of which were related to environmental samples. Conclusion: Next Genome Sequencing is an effective tool to identify multidrug-resistant bacteria transmission clusters in hospitals, thereby proposing effective interventions, minimizing nosocomia outbreaks. Keywords: multidrug resistance A. baumannii, Next Genome Sequencing, transmission cluster
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