Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity

Abstract

Six new compounds including four new xanthones, cylindroxanthones D–G (1–4), and two new biphenyls, cylindrobiphenyls A and B (5 and 6), were isolated from the stems of Garcinia cylindrocarpa together with 28 known compounds (7–34). The structures of the new compounds were established on the basis of extensive 1D and 2D NMR and HRESIMS spectroscopic analysis. Their cytotoxicity was evaluated against five human cancer cell lines including KB, HeLa S-3, MCF-7, Hep G2, and HT-29. Compound 23 showed strong cytotoxicity against KB, HeLa S-3, MCF-7, and Hep G2 cells with IC50 values in the range of 2.20–6.00 μM. Furthermore, compound 25 selectively exhibited good cytotoxicity against MCF-7 cells with IC50 value of 8.77 μM, while 31 showed good cytotoxicity against HT-29 cells with IC50 value of 9.18 μM.