Abstract
Here we present a new drug delivery system based on xanthan esterified with acrylic acid. This material served as a matrix for the incorporation of bioactive substances with antimicrobial and anti-inflammatory properties. The materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) and Scanning Electron Micrography (SEM). Mechanical strength tests showed a substantial improvement in the resilience and flexibility of the polymer matrix modified by esterification under conditions of mechanical stress. The release of bioactive substances from the basic matrix follows a Korsmeyer-Peppas type kinetics. The modified xanthan-based transport system was shown to be antimicrobially active with an inhibition rate of almost 100% on gram-positive and gram-negative bacteria. The obtained results recommend this biomaterial for the manufacture of transdermal drug delivery devices.
Highlights
IntroductionNatural polymers (e.g. cellulose, chitosan, dextran, pullulan, alginate, xanthan, etc.) present a much more attractive alternative compared to synthetic ones, here referring to bioavailability, biocompatibility and biodegradability [1]
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Materials Xanthan (Mw= 2.5 106 Da) from Xanthomonas campestris, Pluronic F-127, 4-toluenesulfonyl chloride (TsCl), pyridine (Py), dicyclohexylcarbodiimide (DCC), methylene chloride, amoxicillin, ketoprofen and human albumin were from Sigma-Aldrich (USA); acrylic acid was from Merck & Co. (USA)
Summary
Natural polymers (e.g. cellulose, chitosan, dextran, pullulan, alginate, xanthan, etc.) present a much more attractive alternative compared to synthetic ones, here referring to bioavailability, biocompatibility and biodegradability [1] Their number is somewhat small but the possibilities to manipulate their properties through appropriate chemical modifications are much higher. Of all these natural polymers, a special category is represented by those that are soluble in water and that have the capacity to modify the properties of the environment in which they are introduced by the ability to swell, thicken or form gels or films. Xanthan seems to be the optimal candidate for food, cosmetic and pharmaceutical applications
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