X-ray structure of the dimeric bis[(1,7-dicarba- closo-dodecaborane-l-carboxylato)-di-n-butyltin] oxide

Abstract

X-ray diffraction studies reveal the structure of {[(1,7-C 2B 10H 11-1-COO)Bu 2Sn] 2O} 12 to be analogous to most other {[RCOO)Bu 2Sn] 2)O} 2 compounds. The dimer features a central Bu 4Sn 2O 2 unit with the two Bu 2Sn groups being linked via bridging oxygen atoms, each of which also carries an exocyclic Bu2Sn moiety. The two pairs of exo- and endo-cyclic tin atoms are each linked via a symmetrically bridging carboxylate ligand and the two remaining ligands coordinate the exocyclic tin atom only, in the monodentate mode. The in vitro anti-tumour activity of this compound, against a variety of cell lines, is compared with those of clinically used compounds.