X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair

P Roethlisberger,C J Leumann,A Stocker,J.-L Reymond,R Visini,M J Marcaida Lopez,A Istrate

doi:10.1039/c6cc00374e

P Roethlisberger, C J Leumann + Show 5 more

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https://doi.org/10.1039/c6cc00374e

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Abstract

DNA duplexes containing unnatural base-pair surrogates are attractive biomolecular nanomaterials with potentially beneficial photophysical or electronic properties. Herein we report the first X-ray structure of a duplex containing a phen-pair in the center of the double helix in a zipper like stacking arrangement.

Highlights

Besides its fundamental biological function, DNA has attracted considerable interest as a foldamer due to its well-ordered supramolecular association properties
We report the first X-ray structure of a duplex containing a phen-pair in the center of the double helix in a zipper like stacking arrangement
In previous work we discovered that multiple replacements of natural bases by bipyridyl, biphenyl or phenanthrenyl residues, devoid of the capability of specific self-recognition, can smoothly be accommodated in the center of a DNA double-helix without compromising duplex stability.[7,8,9,10]

Summary

Introduction

Besides its fundamental biological function, DNA has attracted considerable interest as a foldamer due to its well-ordered supramolecular association properties. J. Leumann et al X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair†

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Conclusion